Multi-course Iodine-131-meta-iodobenzylguanidine in the treatment of metastatic paraganglioma: a case report

VernacularTitle:多疗程碘［ 131I］-间碘苄胍治疗多部位转移性副神经节瘤1例
Author: Yun LI ¹ ; Hongbo GAO ; Longmin LI ; Yujun SHAO ; Xiayang ZHU
Author Information

1. 北京核工业医院核素诊疗中心，北京　102413
Keywords: Paraganglioma; Metastasis; 131I-meta-iodobenzylguanidine
From: Clinical Medicine of China 2024;40(2):114-119
CountryChina
Language:Chinese
Abstract: Paraganglioma (PGL) is a rare neuroendocrine tumor that causes endocrine hypertension. All paragangliomas had metastatic potential. The 5-year survival rate of patients with metastatic paraganglioma is less than 50%, and the treatment is a big problem. Metastatic PGL has a high specific uptake of iodine [ 131I]-meta-iodobenzylguanidine ( 131I-MIBG), so the treatment is effective, well tolerated, and has few adverse reactions. However, there is a lack of relevant detailed clinical diagnosis and treatment data in China. This article reports the diagnosis and treatment of a case of multi-site metastatic paraganglioma with multiple courses of 131I-MIBG, and discusses the efficacy, safety and tolerance of the treatment for clinical reference.