Relationship between plasma fibrinogen/serum albumin ratio and the degree of cerebral artery stenosis in patients with acute cerebral infarction
10.3760/cma.j.cn101721-20230824-00038
- VernacularTitle:血浆纤维蛋白原/血清白蛋白比值与急性脑梗死患者脑动脉狭窄程度的关系
- Author:
Ruijie YANG
1
;
Yang HE
;
Lijuan LI
;
Junjie WANG
;
Ying GUI
;
Lin MA
Author Information
1. 海南医学院第一附属医院神经内科，海口 570102
- Keywords:
Cerebral infarction;
Intracranial atherosclerosis;
Fibrinogen;
Albumin
- From:
Clinical Medicine of China
2024;40(1):60-65
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between plasma fibrinogen/serum albumin ratio (FAR) and the degree of cerebral artery stenosis in patients with acute cerebral infarction (ACI).Methods:Clinical data of 189 patients with acute cerebral infarction diagnosed and treated in the Department of Neurology of the First Affiliated Hospital of Hainan Medical College from January 2021 to March 2023 were selected for retrospective analysis. Digital subtraction angiography (DSA) was improved, and they were divided into four groups according to the degree of intracranial vascular stenosis according to NASCET grading method: no stenosis group (47 cases), mild stenosis group (45 cases), moderate stenosis group (39 cases) and severe stenosis and occlusion group (58 cases). The differences of basic data, plasma fibrinogen/serum albumin ratio (FAR) and other inflammatory indicators among all groups were compared, and the correlation between FAR level and the severity of cerebral artery stenosis was analyzed. Multivariate Logistic regression was used to explore the factors influencing to cerebral artery stenosis and ROC curve was used to evaluate the diagnostic value of FAR in the degree of cerebral artery stenosis in cerebral infarction patients.Results:There were significant differences in blood neutrophil (NEU), mean platelet volume (MPV), fibrinogen (FIB), fibrinogen (FIB), albumin (ALB) and FAR among the 4 groups (statistical values were H=11.50, H=8.44, F=5.16, H=30.93, H=40.38; all P<0.05). Correlation analysis showed a positive correlation between FAR and the degree of cerebral artery stenosis ( r=0.455, P<0.05). Multivariate Logistic regression showed that FAR was an independent risk factor for the degree of cerebral artery stenosis ( OR=1.445, 95% CI=1.261-1.655, P<0.001). Conclusion:FAR is an independent risk factor for cerebral artery stenosis in patients with acute cerebral infarction (ACI), and may be a new biomarker for predicting cerebral artery stenosis.
