Allgrove syndrome: A case report and literature review
10.3760/cma.j.cn101721-20230421-000145
- VernacularTitle:Allgrove综合征1例及文献复习
- Author:
Ni ZHOU
1
;
Yuanyuan WANG
;
Ping MAI
Author Information
1. 江苏大学医学院,镇江 212000
- Keywords:
Allgrove syndrome;
Alacrimia;
Achalasia;
Adrenal insufficiency
- From:
Clinical Medicine of China
2023;39(5):342-346
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the clinical manifestations, diagnosis and treatment of a patient with Allgrove syndrome.Methods:Retrospective analysis of the clinical data of a patient with Allgrove syndrome admitted to Gansu Provincial People's Hospital on August 8, 2018, and review of relevant literature.Results:The patient, female, 20 years old, presented with dysphagia for 10 years and aggravated for 4 years. No tears since childhood. The upper digestive tract barium meal showed that lower esophageal stenosis, a "beak" shaped change. Esophageal manometry suggested multiple peristalsis failures. Laboratory tests showed low plasma cortisol and high ACTH. The clinical diagnosis was Allgrove syndrome. POME was performed to improve dysphagia, and hormone replacement therapy was given. The symptoms were improved after long-term follow-up.Conclusion:Allgrove syndrome is a multisystem disease. The possibility of Allgrove syndrome should be vigilant when suspicious symptoms appear. If necessary, gene detection is helpful for early diagnosis.Treatment, which focuses on the appropriate management of the manifested signs and symptoms, requires the mutual assistance of multiple disciplines.
