Effects of Atorvastatin in Patients with Acute Spinal Cord Injury.
10.4184/asj.2017.11.6.903
- Author:
Javad AGHAZADEH
1
;
Parviz SAMADI MOTLAGH
;
Firooz SALEHPOUR
;
Ali MESHKINI
;
Majid FATEHI
;
Farhad MIRZAEI
;
Seyed Ahmad NASERI ALAVI
Author Information
1. Department of Neurosurgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. dr.arsalan2010@gmail.com
- Publication Type:Clinical Trial ; Original Article
- Keywords:
Wound and injuries;
Spinal cord injuries;
Atorvastatin;
Pain
- MeSH:
Atorvastatin Calcium*;
Follow-Up Studies;
Humans;
Hydroxymethylglutaryl-CoA Reductase Inhibitors;
Hypercholesterolemia;
Incidence;
Prevalence;
Spinal Cord Injuries*;
Spinal Cord*;
Visual Analog Scale
- From:Asian Spine Journal
2017;11(6):903-907
- CountryRepublic of Korea
- Language:English
-
Abstract:
STUDY DESIGN: Clinical trial study. PURPOSE: The aim of this study was to evaluate the effect of atorvastatin on sensory and motor function in patients with acute spinal cord injury. OVERVIEW OF LITERATURE: The prevalence and incidence of traumatic spinal cord injury are increasing. Statins are well established for use in hypercholesterolemia as well as during anti-inflammatory events. METHODS: This clinical trial study included 60 patients with acute spinal cord injury. These were randomly divided into two groups: the case group which received atorvastatin and also underwent surgical therapy and the control group which only underwent surgical therapy. RESULTS: The severity of spinal cord lesions was evaluated based on the Frankel grade at three periods; this showed no significant difference between the two groups. Comparisons of the levels of pain between the groups based on a Visual Analog Scale system showed no significant difference at the three periods. CONCLUSIONS: We observed no improvement at the 3- and 6-month follow-up in patients who were administered atorvastatin. However, a comparison of the two groups based on pain severity demonstrated a significant difference, suggesting that atorvastatin had a positive effect on patients with spinal cord injury.
