Analysis on the assessment value of DCE-MRI quantitative parameters and tumor markers for the curative effect of neoadjuvant chemotherapy for breast cancer
10.3969/j.issn.1672-8270.2024.01.015
- VernacularTitle:动态增强MRI定量参数及肿瘤标记物对乳腺癌新辅助化疗疗效的评估价值分析
- Author:
Rui MA
1
;
Yanhui WANG
;
Min DU
;
Xianlong QI
;
Lin ZHANG
;
Weiwei WANG
Author Information
1. 济宁市第一人民医院磁共振室 济宁 272000
- Keywords:
Dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI);
Tumor marker;
Chemotherapy;
Breast cancer
- From:
China Medical Equipment
2024;21(1):73-77
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the assessment value of quantitative parameters of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)and tumor markers in assessing the curative effect of neoadjuvant chemotherapy for breast cancer.Methods:A total of 75 patients with breast cancer who received neoadjuvant chemotherapy combined with surgical intervention in Jining No.1 People's Hospital from May 2019 to May 2022 were selected,and they were divided into effective group(54 cases)and ineffective group(21 cases)according to the Response Evaluation Criteria In Solid Tumour(RECIST).The Ve,Kep and Ktrans of DCE-MRI quantitative parameters and CEA,CA125 and CA15-3 levels of tumor markers between two groups were compared before and after chemotherapy,and the receiver operating characteristics(ROC)curve was adopted to analyze the predictive efficiency of each diagnostic method.Results:After chemotherapy,the differences of the Ve,Kep and Ktrans of quantitative parameters between the two groups were significant(t=7.237,51.695,16.879,P<0.05),respectively.The differences of the CEA,CA125 and CA15-3 of tumor markers between two groups were significant(t=44.201,6.736,6.885,P<0.05),respectively.The AUC value of combined prediction of 6 indicators included Ve,Kep,Ktrans,CEA,CA125 and CA15-3 was 0.979 in predicting the curative effect of neoadjuvant chemotherapy for breast cancer,which was significantly higher than the AUC value of each alone indicator,and the differences of them were statistically significant(Z=2.993,2.679,2.510,2.731,3.215,3.071,P<0.05),respectively.Conclusion:The combination of tumor markers and DCE-MRI quantitative parameters can better predict the curative effect of neoadjuvant chemotherapy for breast cancer,which can indirectly assess the prognosis.
