Study on the mechanism of lung injury induced by ultra-high dose rate Flash radiation therapy versus traditional radiotherapy
10.3969/j.issn.1672-8270.2024.01.003
- VernacularTitle:闪光放射治疗对比常规放射治疗在放射性肺损伤中的机制探索
- Author:
Yao WANG
1
,
2
;
Wei YU
;
Pei ZHANG
;
Xiangkun DAI
;
Chang LIU
;
Baolin QU
Author Information
1. 解放军总医院第一医学中心放射治疗科 北京 100853
2. 解放军总医院京东医疗区综合内科 北京 101100
- Keywords:
Super-high dose rate;
Flash radiotherapy(Flash-RT);
Radiotherapy with conventional dose rate;
Lung injury;
Radiotherapy technique
- From:
China Medical Equipment
2024;21(1):15-20
- CountryChina
- Language:Chinese
-
Abstract:
Radiotherapy is an important means to treat lung cancer,but it is easy to cause lung injury and reduce the quality of life of patients.Flash radiotherapy(FLASH-RT)has attracted attention due to its extremely short radiation duration and high dose rate,which can reduce toxicity of normal tissue while ensures treatment intensity of tumor.Whether Flash-RT can reduce radiation-induced lung injury has become an important research topic in recent years.Based on the literature analysis method,this review systematically assessed the effects and mechanisms of Flash-RT and radiotherapy with conventional dose rate on lung injury through searching relevant literatures at home and abroad,so as to provide scientific basis for the treatment of patients with lung cancer by reviewing the comparisons about the effects and mechanisms between Flash-RT and radiotherapy with conventional dose rate on lung injury.Compared with radiotherapy with conventional radiation rate,Flash-RT can significantly reduce lung injury and improve quality of life of patients.It is still demanded to explore the Flash-RT mechanism in future,so as to develop the Flash-RT instrument that is suitable for different tumors and to conduct larger-scale clinical researches.
