Research advance of Flash-RT in tumor treatment

VernacularTitle:闪光放射治疗(Flash-RT)在肿瘤治疗中的研究进展
Author: Yuan WANG ¹ ; Lehui DU ; Pei ZHANG ; Qingchao SHANG ; Xingdong GUO ; Jiangyue LU ; Xiao LEI ; Baolin QU
Author Information

1. 解放军总医院第一医学中心放射治疗科北京 100853
Keywords: Flash radiotherapy(Flash-RT); Ultra-high dose rate; Tumor treatment; Mechanism
From: China Medical Equipment 2024;21(1):9-14,20
CountryChina
Language:Chinese
Abstract: The Flash radiotherapy(Flash-RT),which is the key breakthrough in the basic field of radiotherapy technique,which is expected to cause a new major transformation in the field of radiotherapy.In this paper,we reviewed the latest research advances of the application and the mechanism exploration of Flash-RT in tumor treatment.Current studies have found that both the Flash-RT with electron beams and photon and the Flash-RT with proton can reduce injury of normal tissue than radiotherapy with conventional dose-rate,but the relevant mechanisms are not yet clearly understood,which includes but not limited to oxygen depletion,DNA damage,cellular senescence,apoptosis and immune response.The difference of Flash-RT injury between tumor tissue and normal tissue further reduces the limitations of radiotherapy,and reduces the adverse reaction and complication compared with conventional radiotherapy,which has wide application prospects.