Early Detection and Diagnosis of Biliary Atresia in Neonates
10.3969/j.issn.1005-5185.2024.02.019
- VernacularTitle:新生儿胆道闭锁的预警筛查与早期诊断
- Author:
Ya MA
1
;
Ligang CUI
Author Information
1. 北京大学第三医院超声科,北京 100191
- Keywords:
Biliary atresia;
Ultrasonography;
Neonate;
Review
- From:
Chinese Journal of Medical Imaging
2024;32(2):204-208
- CountryChina
- Language:Chinese
-
Abstract:
Biliary atresia is a severe chronic liver disease in infancy that manifests as destructive inflammatory obstructive cholangiopathy.Recent evidence supports that early Kasai procedure by 30 days of life achieves the greatest likelihood of slowing or preventing the need for liver transplant in biliary atresia patients.Unfortunately,the average age at the time of Kasai procedure is around 60 days of life both in China and abroad.The primary reason for this is that there are many difficulties and challenges in early diagnosis.For example,age stratification should be considered when using GGT levels as a screening tool for biliary atresia in infant less than 30 days.What's more,imaging modality such as US shows lower accuracy in very early stage due to milder pathological change in biliary tract,which post challenges on precision medicine and improving prognosis.This article reviewed different early diagnostic methods of screening for biliary atresia,so as to provide a reference for the early diagnosis of biliary atresia,and help discuss the potential development prospect and research direction in the future.
