Ultrasonographic Findings of Xp11.2/TFE3 Translocation Renal Cell Carcinoma
10.3969/j.issn.1005-5185.2024.02.014
- VernacularTitle:Xp11.2易位/TFE3基因融合相关性肾细胞癌的超声表现
- Author:
Juan CHEN
1
;
Diming CAI
Author Information
1. 四川大学华西医院超声医学科,四川 成都 610000
- Keywords:
Renal cell carcinoma;
Ultrasonography;
Xp11.2 translocation;
TFE3 gene fusion;
Pathology,surgical
- From:
Chinese Journal of Medical Imaging
2024;32(2):180-184
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the ultrasound imaging characteristics of Xp11.2 translocation/TFE3 gene fusion renal cell carcinoma(Xp11.2/TFE3-tRCC).Materials and Methods A retrospective analysis was conducted of 10 patients with pathologically confirmed Xp11.2/TFE3-tRCC who underwent surgery in West China Hospital of Sichuan University from April 2009 to February 2022.The ultrasonic images were collected and further analyzed,including tumor border,shape,internal echoes,Doppler findings,and contrast-enhanced ultrasonography findings.Results A total of 10 masses were finally included,4 of which underwent contrast-enhanced ultrasound.The ultrasonographic manifestations of Xp11.2/TFE3-tRCC showed diversity and variability,and the mass was most commonly located in the medulla(5 cases).Conventional ultrasound showed solid nodules with clear boundaries and regular shape similar to benign lesions in 6 cases,and color Doppler showed punctated blood flow signals in 5 cases.Contrast-enhanced ultrasound was more inclined to malignant tumors(3 cases),which showed uneven enhancement,mostly accompanied by peripheral uneven enhancement rings.Conclusion Xp11.2/TFE3-tRCC tends to be benign on conventional ultrasound,while contrast-enhanced ultrasound shows malignant lesions.Therefore,contrast enhanced ultrasound can serve as a potential diagnostic tool for suspected Xp11.2/TFE3-tRCC.
