Changes in Whole-Brain Functional Connectivity Density in Primary Insomnia Based on Resting State Functional MRI
10.3969/j.issn.1005-5185.2023.12.002
- VernacularTitle:基于静息态fMRI的原发性失眠全脑功能连接密度的改变
- Author:
Xuehui REN
1
;
Yulin LIU
;
Jinli WANG
;
Ruixue GAO
;
Hongzhi YANG
;
Bin ZHANG
;
Xiaojun REN
;
Ruwu YANG
;
Zhengwei CHANG
Author Information
1. 西电集团医院医学影像科,陕西 西安 710077
- Keywords:
Functional magnetic resonance imaging;
Primary insomnia;
Functional connectivity density;
Thalamus;
Insula
- From:
Chinese Journal of Medical Imaging
2023;31(12):1244-1249
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the difference of resting-state functional connectivity density(FCD)between chronic primary insomnia patients and healthy controls via resting state functional magnetic resonance imaging(rs-fMRI).Materials and Methods All rs-fMRI data of 35 patients with chronic primary insomnia from Xidian Group Hospital and Xi'an Encephalopathy Hospital of Traditional Chinese Medicine,and 35 healthy controls were prospectively collected from August 2020 to December 2021.The voxel-wise FCD approach was applied to explore the differences of whole-brain functional networks between chronic primary insomnia patients and healthy controls.The relationships between FCD value and Pittsburgh sleep quality index,self-rating scale of sleep,insomnia severity index,self-rating anxiety scale and self-rating depression scale in primary insomnia patients were investigated,respectively.Results Compared with healthy controls,the decreased FCD values were showed in the right insula,bilateral anterior cingulate gyrus,left orbitofrontal middle gyrus,left dorsolateral superior frontal gyrus,right medial superior frontal gyrus and bilateral thalamus(t<-5.271,Padjust<0.05),while the increased FCD values showed in the right superior temporal gyrus,bilateral middle temporal gyrus,bilateral precuneus and left posterior cingulate gyrus(t>4.379,Padjust<0.05)in the chronic primary insomnia patients group.The FCD values of bilateral thalamus(r=-0.620,P<0.001;r=-0.562,P<0.005)and right insula(r=-0.651,P<0.001)were negatively correlated with insomnia severity index in the chronic primary insomnia patients group,respectively.Conclusion The extensive functional connectivity abnormalities are observed in primary insomnia patients via FCD analysis.These findings explain the neural mechanisms of underlying emotional regulation and cognitive impairment in chronic insomnia from the perspective of functional integration and functional separation.
