Clinical-CT model for evaluating lymphovascular and/or perineural invasion of esophageal squamous cell carcinoma
10.13929/j.issn.1003-3289.2024.02.017
- VernacularTitle:临床-CT模型评估食管鳞状细胞癌侵犯脉管和/或神经
- Author:
Hanyu WEI
1
;
Changhua LIANG
;
Siyu ZHEN
;
Xinmiao YANG
;
Yangyang YAO
;
Zhengqi WEI
;
Qiang LI
;
Sijia CHENG
Author Information
1. 新乡医学院第一附属医院放射科,河南新乡 453100
- Keywords:
esophageal neoplasms;
neoplasm metastasis;
tomography,X-ray computed
- From:
Chinese Journal of Medical Imaging Technology
2024;40(2):235-240
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a clinical-CT model,and to observe its value for evaluating lymphovascular invasion(LVI)and/or perineural invasion(PNI)in esophageal squamous cell carcinoma(ESCC).Methods Data of 156 ESCC patients were retrospectively analyzed.The patients were divided into positive group(n=58,LVI[+]and/or PNI[+])and negative group(n=98,LVI[-]and PNI[-])according to postoperative pathological results.Clinical and CT data were compared between groups.Logistic regression analysis was performed to establish a model,and its efficacy of evaluating ESCC LVI and/or PNI was analyzed.Results Significant differences of carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199),tumor thickness,tumor volume and CT venous phase value(CTV),the difference between CTV and CT plain phase value(CTP)(△CTV-P)and venous phase enhancement rate(V％)were found between groups(all P＜0.05),and the area under the curve(AUC)of the above parameters for evaluating ESCC LVI and/or PNI was 0.702,0.690,0.731,0.744,0.621,0.631 and 0.599,respectively.CEA,CA199,tumor thickness,tumor volume and CTV were all independent predictive factors for ESCC LVI and/or PNI.A combined model was established based on the above features,and its accuracy,sensitivity and specificity for evaluating ESCC LVI and/or PNI was 82.05％,65.52％and 91.84％,respectively,with AUC of 0.838,higher than that of each single parameter(all P＜0.05).Conclusion The established clinical-CT model could effectively evaluate ESCC LVI and/or PNI.
