Shear wave elastography for evaluating hepatic iron overload in children with β-thalassemia major:Correlations with MR T2* value and serum ferritin
10.13929/j.issn.1003-3289.2024.01.014
- VernacularTitle:剪切波弹性成像评估重型β-地中海贫血患儿肝脏超铁负荷:与肝脏MR T2*值及血清铁蛋白的相关性
- Author:
Murong CHEN
1
,
2
;
Tingting LIU
;
Weiling CHEN
;
Yafang SUN
;
Sixi LIU
;
Bei XIA
Author Information
1. 汕头大学医学院深圳儿科临床学院,广东深圳 518000
2. 深圳市儿童医院超声影像科,广东深圳 518038
- Keywords:
beta-thalassemia;
iron overload;
child;
ultrasonography
- From:
Chinese Journal of Medical Imaging Technology
2024;40(1):73-76
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of shear wave elastography(SWE)for evaluating hepatic iron overload in children with β-thalassemia major(β-TM),as well as the correlations of relative parameters with MR T2*value and serum ferritin.Methods Totally 96 children with β-TM and 100 healthy children(control group)were retrospectively enrolled.Children with β-TM were divided into hematopoietic stem cell transplantation(HSCT)group(n=41)or non-HSCT group(n=55)according to underwent HSCT or not.SWE parameters were compared among groups.Spearman correlation was performed to observe the correlations of liver shear wave velocity with MR T2*value and serum ferritin,as well as Young's modulus with MR T2*value and serum ferritin in children with β-TM.Results Liver shear wave velocity(LSWV)and Young's modulus in HSCT group and non-HSCT group were all higher than those in control group(all P＜0.001).No significant difference of LSWV nor Young's modulus was found between HSCT group and non-HSCT group(both P＞0.05).SWE parameters of children with β-TM were moderately and negatively correlated with MR T2*value(r=-0.501,P＜0.05;r=-0.514,P＜0.05),while weakly and positively correlated with serum ferritin(r=0.488,P＜0.05;r=0.470,P＜0.05).Conclusion SWE was helpful for evaluating hepatic iron overload in children with β-TM,with parameters being negatively correlated with MR T2*value and positively correlated with serum ferritin.
