18F-FDOPA PET/CT for evaluating efficacy of radiotherapy combined with chemotherapy for advanced glioma
10.13929/j.issn.1003-3289.2024.01.005
- VernacularTitle:18F-FDOPA PET/CT评估放射化学治疗用于高级别脑胶质瘤效果
- Author:
Guojin MA
1
;
Jiajing LI
;
Jinli CUI
;
Xiuyu LIN
Author Information
1. 长春中医药大学附属医院医学影像科,吉林长春 130021
- Keywords:
glioma;
radiotherapy;
drug therapy;
positron-emission tomography
- From:
Chinese Journal of Medical Imaging Technology
2024;40(1):27-31
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of 18F-fluoro-dihydroxy-phenylalanine(18F-FDOPA)PET/CT for evaluating the efficacy of radiochemotherapy for advanced glioma.Methods Data of 84 patients with advanced glioma who received precision radiotherapy combined with synchronous chemotherapy were retrospectively analyzed.The patients were divided into effective group(complete remission+partial remission+stable disease,n=60)and ineffective group(progressive disease,n=24)according to the efficacy of radiochemotherapy.18F-FDOPA PET/CT metabolic parameters of tumors,including tumor metabolic tumor volume(MTV),maximum standard uptake value(SUVmax)and mean standard uptake value(SUVmean)were compared between groups,also before and after radiochemotherapy within groups.Spearman correlation analysis was used to observe the correlations of metabolic parameters and the efficacy of radiochemotherapy.Results After radiochemotherapy,MTV,SUVmax and SUVmean of tumors in effective group were lower than those of tumors in ineffective group(all P＜0.05).Significant differences of metabolic parameters were found before and after radiochemotherapy in effective group(all P＜0.05).MTV,SUVmax and SUVmean of advanced glioma were negatively correlated with the efficacy of radiochemotherapy(r=-0.63,-0.52,-0.50,P＜0.001,P=0.007,P=0.010).Conclusion 18F-FDOPA PET/CT was helpful for evaluating the efficacy of radiochemotherapy for advanced glioma.
