Multiparameter MRI for follow-up observation on changes of spinal cord microstructures in patients with hereditary spastic paraplegias type 5
10.13929/j.issn.1003-3289.2024.01.003
- VernacularTitle:多参数MRI随访观察遗传性痉挛性截瘫5型患者脊髓微结构改变
- Author:
Chenlin LIN
1
,
2
;
Fan ZHANG
;
Mengcheng LI
;
Ying FU
;
Ying LIU
Author Information
1. 福建医科大学附属第一医院医学影像科,福建福州 350005
2. 福建医科大学附属第一医院滨海院区国家区域医疗中心医学影像科,福建福州 350212
- Keywords:
spastic paraplegia,hereditary;
spinal cord;
magnetic resonance imaging
- From:
Chinese Journal of Medical Imaging Technology
2024;40(1):14-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of multiparameter MRI for follow-up observation on changes of spinal cord microstructures in patients with hereditary spastic paraplegias type 5.Methods Eleven patients with SPG5 who underwent cervico-thoracic spinal cord MR examination and spastic paraplegia rating scale(SPRS)were prospectively enrolled.The second MR examination and SPRS were completed after 1 year follow-up,and the changes of SPRS score,the overall structures and microstructures of spinal cord were compared.Results No significant difference of SPRS scores was found(P＞0.05).Compared to the first cervico-thoracic spinal cord MR examination,atrophy of spinal cord aggravated in the second time MRI.Significant difference of axial diffusivity of C4 right corticospinal tract(CST)was found(t=3.987,P＜0.01),but not of the other parameters of C4(all P＞0.05)between the first and the second time MRI.No significant difference of fractional anisotropy(FA),mean diffusivity(MD),AD,radial diffusivity(RD)nor T1 value of the other centrums'white matter,posterior funiculus or bilateral CST in spinal cord was found between the first and the second time MRI(all P＞0.05).Meanwhile,no significant difference of CSA,left and right diameter nor anteroposterior diameter of C1-T9 was found between the first and second time MRI(all P＞0.05).FA value of white matter,posterior funiculus and bilateral corticospinal tract in cervical spinal cord were all lower,whereas RD value at the above position were all higher in the second time MRI than those in the first time MRI(all P＞0.05).Conclusion Multiparameter MRI could be used for follow-up observation on changes of microstructure spinal cord in patients with hereditary spastic paraplegias type 5.
