18F-FDG PET/CT combined with tumor markers for diagnosis of non stage ⅠA limited-stage small cell lung cancer
10.13929/j.issn.1003-3289.2023.12.016
- VernacularTitle:18F-FDG PET/CT联合肿瘤标志物诊断非ⅠA期局限性小细胞肺癌
- Author:
Shuai LIN
1
;
Yumeng JIANG
;
Qi WANG
;
Wenwen JIANG
;
Chaowei LI
;
Fei JIN
;
Lei ZENG
;
Cuiyu LIU
;
Haiying ZHANG
;
Na FANG
;
Yanli WANG
Author Information
1. 青岛大学第二临床医学院青岛大学附属青岛市中心医院分子影像科PET/CT中心,山东青岛 266042
- Keywords:
lung neoplasms;
biomarkers,tumor;
positron emission tomography;
tomography,X-ray computed
- From:
Chinese Journal of Medical Imaging Technology
2023;39(12):1813-1818
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of 18F-FDG PET/CT combined with tumor markers for diagnosis of non stageⅠ A limited-stage small cell lung cancer(LS-SCLC).Methods Totally 87 cases of non stage Ⅰ A LS-SCLC(LS-SCLC group),137 of non stage Ⅰ A non-small cell lung cancer(NSCLC,NSCLC group)and 48 cases of pulmonary inflammatory lesions(inflammatory group)were enrolled.Patients'general data,tumor marker levels and PET/CT findings were comparatively analyzed.Logistic regression analysis was performed to evaluate the efficacy of parameters for diagnosing non stage Ⅰ A LS-SCLC.Results There were significant differences of patients'age,neuron-specific enolase(NSE),pro-gastrin-releasing peptide(ProGRP),carcinoembryonic antigen(CEA),squamous cell carcinoma antigen(SCCA)and cytokeratin-19-fragment(CYFRA21-1),as well as of the maximum lesion diameter,maximum standard uptake value(SUVmax),morphology,spiculation sign,relationship between long axis and bronchus,lymph node fusion and proportion of lymph node with higher SUVmax than primary lesion among 3 groups(all P＜0.05).The area under the curve(AUC)of the combination of spiculation sign,NSE＞23.5 μg/L,ProGRP＞111.8 ng/L,SCCA≤2.5 μg/L and CYFRA21-1≤7.4 μg/L for differentiating LS-SCLC and NSCLC was 0.91,higher than that of each single parameter(all P＜0.05).AUC of the combination of SUVmax＞8.1,NSE＞19.4 μg/L,ProGRP＞72.5 ng/L and lymph node fusion for differentiating LS-SCLC and pulmonary inflammatory lesions was 0.99,higher than each single parameter(all P＜0.05).Conclusion 18F-FDG PET/CT combined with tumor markers ProGRP and NSE was helpful for diagnosing non stage ⅠA LS-SCLC.
