18F-FDG PET/CT manifestations of primary systemic anaplastic large cell lymphoma
10.13929/j.issn.1003-3289.2023.12.013
- VernacularTitle:原发系统性间变性大细胞淋巴瘤18F-FDG PET/CT表现
- Author:
Lu ZHENG
1
;
Yujing HU
;
Xinchao ZHANG
;
Kang LI
;
Xiaoyu CAI
;
Jiale LIU
;
Yanzhu BIAN
Author Information
1. 河北省人民医院核医学科,河北石家庄 050051;河北省脑网络与认知障碍疾病重点实验室,河北石家庄 050051
- Keywords:
lymphoma;
positron-emission tomography;
tomography,X-ray computer;
fluorodeoxyglucose F18
- From:
Chinese Journal of Medical Imaging Technology
2023;39(12):1798-1802
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the 18F-FDG PET/CT manifestations of primary systemic anaplastic large cell lymphoma(ALCL).Methods A total of 21 patients with primary systemic ALCL were enrolled,and PET/CT manifestations were observed.Results Among 21 cases of ALCL,there were 15 cases of ALK+and 6 cases of ALK-.Affected lymph nodes in multiple site were observed in 19 cases,mainly located in the neck(n=13),mediastinum(n=12 cases)or retroperitoneum(n=12),while single site affected lymph node was notice in 2 cases.Extranodal organs/site involvements were found in 12 cases,including 6 cases of soft tissue(such as skin,muscles,etc.),4 cases of bone,14 cases of organs,including 4 cases of lung,3 cases of liver,2 cases of pancreas,2 cases of kidney,2 cases of gastrointestinal tract and 1 case of thyroid.Among 21 cases of ALCL,19 with irregular lymph node morphology and fused into clusters,17 with uniform density,3 with necrosis and 1 with calcification.All ALCL lesions in 21 cases showed hypermetabolism,the maximum standard uptake value(SUVmax)and the mean standard uptake value(SUVmean)of the affected lymph node was 17.04±9.94 and 9.96±6.15,respectively,while the metabolic tumor volume(MTV)and total lesion glycolysis(TLG)of all lesions was 92.54(67.61,249.21)cm3 and 723.46(419.78,1 461.17)g,respectively.The maximum diameter of the affected lymph node was not significantly correlated with SUVmax nor SUVmean(both P＞0.05),but positively correlated with MTV and TLG of all lesions(r=0.696,0.767,both P＜0.001).Ann Arbor staging was positively correlated with the maximum diameter,SUVmax and SUVmean of the affected lymph node,also MTV and TLG of all lesions(r=0.467,0.458,0.702,0.780,0.664,all P＜0.05).Conclusion 18F-FDG PET/CT manifestations of primary systemic ALCL were characteristic,with significant changed metabolic parameters,including SUVmax,SUVmean,MTV and TLG.
