Ultrasonic manifestations and genetic abnormalities in the second trimester of pregnancy of fetal congenital kidney anomalies
10.13929/j.issn.1003-3289.2023.12.004
- VernacularTitle:胎儿先天性肾脏异常孕中期超声表现及遗传学异常
- Author:
Huiping ZHANG
1
;
Yuqing ZHOU
;
Yuanqing GUO
;
Liyun FENG
;
Biyuan HE
Author Information
1. 上海市长宁区妇幼保健院华东师范大学附属妇幼保健院超声医学科,上海 200051
- Keywords:
fetus;
kidney diseases;
genes;
chromosomes;
ultrasonography
- From:
Chinese Journal of Medical Imaging Technology
2023;39(12):1775-1778
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the ultrasonic manifestations and genetic abnormalities in the second trimester of pregnancy of fetal congenital kidney anomalies(CKA).Methods Totally 14 singleton pregnancy women with CKA fetus detected with prenatal ultrasound and proved by genetic examination who underwent prenatal ultrasound in the second trimester of pregnancy were enrolled.The ultrasonic manifestations and genetic abnormalities in the second trimester of pregnancy were observed.Results Among 14 fetuses,simple renal abnormalities were detected in 10,while renal abnormalities complicated with extrarenal abnormalities were noticed in 4 fetuses with prenatal ultrasound in the second trimester of pregnancy,presented as enhanced renal echoes,renal pelvis separation and ectopic kidney,etc.Genetic examination showed chromosomal karyotype abnormalities in 4 fetuses,chromosomal copy number abnormalities in 8 fetuses,and genetic mutations in 2 fetuses.Conclusion The ultrasonic manifestations in the second trimester of pregnancy of fetal CKA included enhanced renal echo,renal pelvis separation and ectopic kidney,etc.Severe chromosomal or genetic abnormalities could exist even when the relative manifestations were not obvious.
