Bioelectromagnetic dosimetric study of human blood-brain barrier opening induced by electromagnetic pulse
10.3969/j.issn.1005-202X.2024.02.018
- VernacularTitle:电磁脉冲引起人体血脑屏障开放的生物电磁剂量学
- Author:
Jiajin LIN
1
;
Yan ZHOU
;
Guirong DING
;
Jing LI
Author Information
1. 空军军医大学军事预防医学系辐射防护医学教研室/特殊作业环境危害评估与防治教育部重点实验室,陕西西安 710032
- Keywords:
electromagnetic pulse;
blood-brain barrier;
clinical application;
dose;
biosafety
- From:
Chinese Journal of Medical Physics
2024;41(2):241-246
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the bioelectromagnetic dose of human blood-brain barrier opening induced by electromagnetic pulse.Methods A typical exposure platform was used to establish an environment for human brain dosimetric study.The bioelectromagnetic dose was evaluated with electromagnetic simulation method using a 3D digital human model.Results The electric field at the centre of the head reached a peak of 1.49 kV/m,and there was a decrease of 41.6 dB from the excitation field.The maximum electric field amplitude on the surface of the nose tip was 1795 kV/m.The head had an average absorption rate of 4.16×10-8 J/kg under one pulse,while under extreme conditions with a repetition frequency of 1000 s-1,the average specific absorption rate of the head was 4.16×10-5 W/kg.Conclusion Local high-intensity electric fields pose significant safety risks in clinical application,and it is necessary to study the means of inhibiting local high-intensity electric field in combination with the dose-effect relationship of blood-brain barrier opening.The human brain bioelectromagnetic doses provided by the study can be used to evaluate the clinical efficacy.
