Application of non-invasive inflammation diagnosis model in the diagnosis of non-alcoholic fatty liver disease and liver fibrosis in patients with combined hepatitis B virus infection
10.3760/cma.j.cn431274-20230322-00389
- VernacularTitle:无创炎症诊断模型在非酒精性脂肪性肝病合并乙型肝炎病毒感染患者肝纤维化诊断中的应用
- Author:
Xuguang WU
1
;
Lihua MA
;
Guoxiang ZHAN
;
Zhigang HUANG
Author Information
1. 中国人民武装警察部队海警总队医院感染科，嘉兴 314001
- Keywords:
Non-alcoholic fatty liver disease;
Hepatitis B;
Hepatic fibrosis;
Diagnostic model for inflammation
- From:
Journal of Chinese Physician
2024;26(2):245-249
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the application value of non-invasive inflammation diagnosis model in the diagnosis of liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) combined with hepatitis B virus (HBV) infection.Methods:A total of 98 patients with NAFLD complicated with HBV infection admitted to some coastal China Coast Guard Hospital of People′s Armed Police from June 2019 to October 2021 were selected. Their liver stiffness (LSM), aspartate aminotransferase to platelet ratio (APRI), γ-glutamyltranspeptidase to platelet ratio (GPR), and fibrosis index based on factor 4 (FIB-4) were measured, The receiver operating characteristic (ROC) curve was used to analyze its clinical diagnostic efficacy for liver fibrosis caused by NAFLD combined with HBV infection.Results:Among 98 patients, there were 7 cases in S0 stage, 47 cases in S1 stage, 21 cases in S2 stage, 14 cases in S3 stage, and 9 cases in S4 stage; Including 35 cases of obvious liver fibrosis and 9 cases of cirrhosis. There was no statistically significant difference in gender and body mass index (BMI) among patients in different stages (all P>0.05). Age: the S0 group
