The therapeutic effect of Kuijie enema combined with Western medicine on patients with ulcerative colitis
10.3760/cma.j.cn431274-20230724-00029
- VernacularTitle:溃结灌肠液联合西医对溃疡性结肠炎患者的疗效
- Author:
Ji LIU
1
;
Bin SHI
;
Xueli ZENG
Author Information
1. 十堰市人民医院（湖北医药学院附属人民医院）中医科，十堰 442000
- Keywords:
Colitis, ulcerative;
Ulcerative enema solution;
Traditional Chinese medicine therapy
- From:
Journal of Chinese Physician
2024;26(2):240-244
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the therapeutic effect of traditional Chinese medicine formula Kuijie enema combined with Western medicine on patients with ulcerative colitis.Methods:A clinical prospective randomized trial was conducted, and 107 patients with ulcerative colitis admitted to the Shiyan People′s Hospital from January 2018 to December 2022 were included in the study. They were randomly divided into a combination group of 54 cases and a control group of 53 cases using a random number table method. Both groups of patients received the same basic treatment plan, and the combination group was treated with traditional Chinese medicine formula for ulcerative colitis enema on this basis. Both groups of patients were treated continuously for 4 weeks, We observed the differences in serum inflammatory factors [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10), monocyte chemokine 1 (MCP1)], Mayo score, endoscopic mucosal score, traditional Chinese medicine symptom score, and clinical treatment efficacy between two groups of patients before and after treatment.Results:After treatment, the serum levels of TNF-α, IL-6, and MCP1 in the two groups were lower than those before treatment, and IL-10 was higher (all P<0.05), and the changes of the above inflammatory factors were more obvious in the combined group, with statistically significant differences (all P<0.05). After treatment, the Mayo score and endoscopic mucosal score of both groups of patients decreased compared to before treatment (all P<0.05), and the Mayo score and endoscopic mucosal score of patients in the combination group were lower than those in the control group (all P<0.05). After treatment, the traditional Chinese medicine syndrome scores of both groups decreased compared to before treatment (all P<0.05), and the combined group patients had lower scores for diarrhea, abdominal pain, pus and bloody stools, urgency and weight, and anal burning than the control group, with statistical significance (all P<0.05). Both groups of patients were treated continuously for 4 weeks, and the overall efficacy distribution of the combination group was better than that of the control group ( Z=-2.274, P=0.023). Conclusions:The combination of traditional Chinese medicine formula Kuijie enema liquid and Western medicine can more effectively reduce the degree of inflammation in patients with ulcerative colitis, alleviate clinical symptoms, and improve clinical treatment effectiveness.
