Adiponectin gene polymorphism and postpartum type 2 diabetes in pregnant women with gestational diabetes mellitus
10.3760/cma.j.cn431274-20230424-00547
- VernacularTitle:妊娠期糖尿病患者脂联素基因多态性与产后发生2型糖尿病的关系
- Author:
Xianghua LYU
1
;
Yun CHAI
;
Na XIAN
;
Yanan ZHANG
;
Yaqi FENG
;
Danni XU
;
Huamei JIANG
Author Information
1. 济宁医学院附属医院产科，济宁 272100
- Keywords:
Diabetes, gestational;
Adiponectin;
Polymorphism, single nucleotide;
Diabetes mellitus, type 2
- From:
Journal of Chinese Physician
2024;26(2):191-195
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between adiponectin (ADIPOQ) gene polymorphism and postpartum type 2 diabetes mellitus (T2DM) in pregnant women with gestational diabetes mellitus (GDM).Methods:A retrospective study was conducted on 236 GDM postpartum women admitted to the Affiliated Hospital of Jining Medical College from June 2020 to June 2021 as observation subjects. They were divided into a T2DM group and a non T2DM group based on the occurrence of T2DM after delivery. The clinical data of the two groups were compared. The double deoxygenation end termination method was used to detect the single nucleotide polymorphism (SNP) of the ADIPOQ gene, and the four loci rs17366568, rs822395, rs1501299, and rs2241766 were classified. The relationship between ADIPOQ genotype polymorphism and postpartum T2DM was analyzed using a logistic regression model.Results:The G allele carrying the rs2241766 locus in ADIPOQ gene was negatively correlated with the occurrence of T2DM ( OR=0.71, 0.68, P<0.05). Compared with T2DM patients with TT genotype, the GT+ GG genotype at the rs2241766 locus had a lower risk of occurrence for gestational age ≥2 and HbA 1c>85%. Similarly, T2DM patients with pre pregnancy body mass index (BMI)>25 kg/m 2 were more likely to be carriers of the rs2241766 TT genotype ( P=0.026). The (GT+ TT) genotype carrying the T allele at the rs1501299 locus was a protective factor for gestational age and HbA 1c in T2DM patients. Conclusions:The rs2241766 and rs1501299 polymorphisms of the ADIPOQ gene are associated with susceptibility to postpartum T2DM in GDM women. Individuals with rs2241766 and rs1501299 mutant genotypes belong to the high-risk population for T2DM.
