Current research status of mesenchymal stem cell therapy for chronic obstructive pulmonary disease

VernacularTitle:间充质干细胞治疗慢性阻塞性肺疾病的研究现状
Author: Xueting WAN ¹ ; Hong YANG ; Jun WANG ; Zhaoyun PENG ; Yujuan CHEN
Author Information

1. 山东中医药大学第一临床医学院，济南　250014
Keywords: Mesenchymal stem cells; Pulmonary disease, chronic obstructive
From: Journal of Chinese Physician 2024;26(1):156-160
CountryChina
Language:Chinese
Abstract: Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung condition characterized by persistent airflow obstruction caused by long-term airway inflammation or alveolar abnormalities, often manifested as chronic respiratory symptoms and decreased lung function. In recent years, experimental research has shown that mesenchymal stem cells (MSC) have anti-inflammatory, immunomodulatory, and repairing properties of lung epithelial cells, which can be used to treat various diseases including COPD. This article is mainly based on the main findings of in vitro and in vivo animal model experiments and clinical studies of MSC treatment for COPD. It summarizes and discusses the possible mechanisms of action of MSC as a new therapy, and provides new ideas for clinical treatment of COPD.