Research progress on SENP1/HIF-1α regulation of vascular differentiation of dental pulp stem cells

VernacularTitle:SENP1/HIF-1α调控牙髓干细胞成血管分化的研究进展
Author: Juan TANG ¹ ; Donglin YU ; Honghai FU
Author Information

1. 滨州医学院附属医院口腔颌面外科，滨州　256603
Keywords: Hypoxia-inducible factor 1, alpha subunit; Small ubiquitin modifier protease 1; Dental pulp stem cells; Vascular endothelial growth factors
From: Journal of Chinese Physician 2024;26(1):146-150
CountryChina
Language:Chinese
Abstract: Dental pulp stem cells (DPSC) are pluripotent stem cells with high differentiation potential isolated from dental pulp. Using DPSC for vascular regeneration may be a good option. Hypoxia inducible factor-1α (HIF-1α) is an upstream gene of vascular endothelial growth factor (VEGF), and the small ubiquitin like protease 1 (SENP1) can reverse the small ubiquitin like (SUMO) modification of HIF-1α. Through the regulation of SENP1/HIF-1α, good vascular regeneration characteristics have been demonstrated in many in vitro and in vivo experiments. The SENP1/HIF-1α signaling axis has varying degrees of promoting and inhibiting effects on many solid tumors. Although there is relatively little literature on the role of the SENP1/HIF-1α signaling axis in dental pulp stem cells, it can be determined that SENP1/HIF-1α plays an important role in the angiogenesis of dental pulp stem cells. This article will elucidate the SENP1/HIF-1α signaling pathway and its mechanism of promoting vascular differentiation of DPSC.