Research progress on the mechanism of ferroptosis on osteosarcoma

VernacularTitle:铁死亡对骨肉瘤作用机制的研究进展
Author: Yize YAN ¹ ; Long YUAN ; Wanxiang LI ; Sen LI ; Jichao BIAN ; Guodong WANG
Author Information

1. 济宁医学院临床医学院，济宁　272002
Keywords: Ferroptosis; Osteosarcoma
From: Journal of Chinese Physician 2024;26(1):142-146
CountryChina
Language:Chinese
Abstract: Osteosarcoma is the most common malignant bone tumor disease in young children and young people. It usually has strong invasiveness, and conventional treatment cannot achieve the expected results. Therefore, studying the mechanism of tumor cell death and exploring more effective treatment methods is of great significance. As a new form of cell death, ferroptosis has been found to have three main regulatory pathways closely related to tumor cell molecular mechanisms, genes, etc. This provides a theoretical basis for the application of ferroptosis in the treatment of osteosarcoma. This article reviews recent research on the interaction between ferroptosis and osteosarcoma in regulating molecules, genes, and other factors, as well as the application of ferroptosis in the treatment of osteosarcoma.