Research progress of LncRNA NEAT1 in lung diseases
10.3760/cma.j.cn431274-20230326-00405
- VernacularTitle:LncRNA NEAT1在肺部疾病中的研究进展
- Author:
Wenyan ZHOU
1
;
Liyi QIAO
;
Yi ZHANG
;
Guangyu LIU
;
Tianbo XIE
;
Jing YAO
Author Information
1. 南京医科大学第二临床医学院，南京 211166
- Keywords:
RNA, long noncoding;
NEAT1 gene;
Lung diseases
- From:
Journal of Chinese Physician
2023;25(12):1917-1920
- CountryChina
- Language:Chinese
-
Abstract:
Long chain non coding RNA (LncRNA) is widely involved in various biological processes such as intracellular chromatin modification, transcriptional regulation, nuclear transport, and protein function regulation, and is closely related to various key physiological functions such as immunity and metabolism in the body. NEAT1 (nuclear parapackle assembly transcript 1) is a newly discovered LncRNA, which is an important component of the nuclear substructural paraplaques. It has been proven to regulate downstream protein expression by binding to various miRNAs, thereby regulating the expression of inflammatory factors, epithelial mesenchymal transition, autophagy, apoptosis, proliferation, migration, and other biological processes, Its abnormal expression plays an important role in the pathogenesis of lung diseases such as asthma, chronic obstructive pulmonary disease, pneumonia, pulmonary fibrosis, and lung cancer, and is closely related to the prognosis of non-small cell lung cancer and the sensitivity of anti-tumor drugs. It is expected to become a new biological marker and therapeutic intervention target. This article mainly reviews the latest research progress on the role of NEAT1 in lung diseases.
