The characteristics and clinical significance of ascites and peripheral blood lymphocyte subpopulations in decompensated liver cirrhosis patients with alcoholic liver disease
10.3760/cma.j.cn431274-20230113-00047
- VernacularTitle:酒精性肝病失代偿期肝硬化患者腹水和外周血淋巴细胞亚群的特征及临床意义
- Author:
Feng YANG
1
;
Aimei LI
;
Cong WANG
Author Information
1. 济宁医学院附属医院消化内科，济宁 272000
- Keywords:
Liver diseases, alcoholic;
Decompensated cirrhosis;
Ascites;
Lymphocyte subsets
- From:
Journal of Chinese Physician
2023;25(11):1682-1686
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the characteristics and clinical significance of ascites, peripheral blood lymph nodes, and cell subpopulations in patients with decompensated liver cirrhosis caused by alcoholic liver disease.Methods:Sixty decompensated liver cirrhosis patients with alcoholic liver disease admitted to the Affiliated Hospital of Jining Medical Unversity from July 2020 to July 2022 were selected as the observation group, and 40 healthy volunteers who underwent physical examinations in our hospital were randomly selected as the control group. The observation group was divided into A, B, and C grades based on the severity of the condition, according to the Child-Pugh grading of liver function. The differences in clinical data, peripheral blood lymphocyte subpopulation indicators, and ascites lymphocyte subpopulation indicators (CD3 + , CD4 + , CD8 + , CD20 + ) under different disease grades were analyzed, and the differences in peripheral blood lymphocyte subpopulation indicators between the two groups of people were compared. Resultsl:The levels of CD3 + , CD4 + , CD8 + , CD4 + /CD8 + , and CD20 + in the observation group were significantly lower than those in the control group (all P<0.05). Compared with Child-Pugh A grade patients, the expression of CD3 + , CD4 + , CD8 + , CD4 + /CD8 + , and CD20 + in peripheral blood of Child-Pugh B and C grade patients decreased significantly (all P<0.05); Compared with Child-Pugh B grade patients, the expression of CD3 + , CD4 + , CD8 + , CD4 + /CD8 + , and CD20 + in peripheral blood of Child-Pugh C grade patients decreased significantly (all P<0.05). Compared with Child-Pugh A grade patients, the expression of CD3 + , CD4 + , CD8 + , CD4 + /CD8 + , and CD20 + in ascites of Child-Pugh B and C grade patients decreased significantly (all P<0.05); Compared with Child-Pugh B grade patients, the expression of CD3 + , CD4 + , CD8 + , CD4 + /CD8 + , and CD20 + in ascites of Child-Pugh C grade patients decreased significantly (all P<0.05). The peripheral blood and ascites lymphocyte subsets were negatively correlated with the Child-Pugh grading of decompensated liver cirrhosis in alcoholic liver disease (all P<0.05). Conclusions:Patients with decompensated liver cirrhosis caused by alcoholic liver disease are accompanied by varying degrees of immune dysfunction. Detection of lymphocyte subsets in the patient′s peripheral blood and ascites has significant clinical significance for the diagnosis and prognosis of this disease.
