Ginkgo biloba extract dense tablets combined with pitavastatin for the treatment of elderly stable coronary heart disease: a prospective study
10.3760/cma.j.cn431274-20221229-01369
- VernacularTitle:银杏酮酯分散片联合匹伐他汀治疗老年稳定性冠心病的临床研究
- Author:
Dejie ZHANG
1
;
Shanshan WANG
Author Information
1. 中国人民解放军联勤保障部队第九二八医院，海口 570000
- Keywords:
Coronary disease;
Ginkgo ketoester dispersible tablets;
Pitavastatin
- From:
Journal of Chinese Physician
2023;25(10):1520-1524
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical efficacy of ginkgo biloba extract dense tablets combined with pitavastatin in the treatment of elderly stable coronary heart disease (SCAD), as well as its impact on patients′ thrombotic status, neutrophil-to-lymphocyte ratio (NLR), and serum high-sensitivity C-reactive protein (hs-CRP) levels.Methods:A prospective study was conducted on 82 elderly SCAD patients admitted to the 928th Hospital of PLA Joint Logistics Support Force from October 2019 to December 2020. The patients were divided into an observation group and a control group using a random number table method, with 41 patients in each group. The control group received oral pitavastatin calcium tablets, while the observation group received oral ginkgo biloba extract dense tablets on the basis of the control group. After 8 weeks of continuous treatment, the clinical efficacy of the two groups was observed. The frequency of angina attacks, thrombotic status indicators [D-dimer (D-D), fibrinogen (FIB)], peripheral blood NLR, serum hs-CRP levels were compared before and after treatment between the two groups. The incidence of adverse reactions was compared between the two groups.Results:The total effective rate of the observation group was 78.05%(32/41), which was significantly higher than 56.10%(23/41) of the control group, and the difference was statistically significant ( P<0.05). After treatment, the frequency of angina attacks [weekly attack times, duration of single attack, severity (weekly nitroglycerin usage)] in both groups significantly improved compared with before treatment (all P<0.05), and the observation group improved more significantly (all P<0.05). After treatment, plasma D-D and FIB levels in both groups significantly decreased compared with before treatment (all P<0.05), and the observation group decreased more significantly (all P<0.05). Peripheral blood NLR and serum hs-CRP levels in both groups significantly decreased compared with before treatment (all P<0.05), and the observation group was significantly lower than the control group (all P<0.05). There was no significant difference in the incidence of adverse reactions between the observation group and the control group [9.76%(4/41) vs 7.32%(3/41)] ( P>0.05). Conclusions:The overall efficacy of ginkgo biloba extract dense tablets combined with pitavastatin in the treatment of elderly SCAD is exact, which can effectively improve patients′ angina attacks, thrombotic status and inflammatory state with good safety.
