Recent advances in anticoagulation reversal of oral anticoagulant-associated intracerebral hemorrhage
10.3760/cma.j.cn431274-20221112-01166
- VernacularTitle:口服抗凝剂相关脑出血逆转方案的研究进展
- Author:
Yusen ZHOU
1
;
Jiangliu YIN
;
Lijun HU
;
Yong GONG
Author Information
1. 南华大学附属长沙中心医院神经外科，长沙 410004
- Keywords:
Anticoagulants, oral;
Cerebral hemorrhage;
Anticoagulation reversal
- From:
Journal of Chinese Physician
2023;25(9):1435-1440
- CountryChina
- Language:Chinese
-
Abstract:
With the progressive aging of the population and the attendant increase in oral anticoagulants (OAC) use, studies have shown that the risk of intracerebral hemorrhage (ICH) in patients receiving OAC treatment is 7-10 times higher than that in patients not receiving OAC treatment. Moreover, compared to general ICH patients, patients with oral anticoagulant-associated intracerebral hemorrhage (OAC-ICH) exhibit larger ICH-volumes, have higher mortality, and importantly have a greater frequency of hematoma expansion (HE). Hence, aggressive and specific medical management to reverse anticoagulation irrespective of vitamin K antagonists (VKA) or new oral anticoagulants (NOAC) used is essential to reduce HE rates and thereby to potentially influence clinical outcomes. This paper aims to compare and analyze the history and latest progress of reversal scheme in different OAC, so as to provide a theoretical basis for patients with OAC-ICH to pick a more reasonable reversal scheme.
