Ferroptosis and Parkinson′s disease
10.3760/cma.j.cn431274-20221208-01293
- VernacularTitle:铁死亡与帕金森病
- Author:
Xi LI
1
;
Benchi CAI
;
Tao CHEN
Author Information
1. 海南省人民医院神经内科，海口 570311
- Keywords:
Ferroptosis;
Parkinson disease
- From:
Journal of Chinese Physician
2023;25(9):1418-1422
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson′s disease is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra. Research has confirmed that Fe deposition in the substantia nigra is an important factor in the degeneration of dopaminergic neurons. Ferroptosis is a new form of Fe dependent cell death first reported in 2012, and there is currently little research on iron death in Parkinson′s disease. This article introduces the formation process and pathological changes of ferroptosis from several aspects such as iron homeostasis, ferroptosis, and lipid peroxidation, as well as the relationship between ferroptosis and Parkinson′s disease.
