The function mechanism of FANCD2 and its research progress in tumors

VernacularTitle:FANCD2的作用机制及其在肿瘤中的研究进展
Author: Liming ZHANG ¹ ; Lina WANG ; Shaoqiang WANG
Author Information

1. 济宁医学院临床医学院，济宁　272000
Keywords: Fanconi anemia complementation group D2 protein; Neoplasms; DNA damage; Ferroptosis
From: Journal of Chinese Physician 2023;25(9):1414-1418
CountryChina
Language:Chinese
Abstract: Fanconi anemia (FA) is an autosomal recessive inherited disease and the most common hereditary bone marrow failure syndrome, which can lead to bone marrow failure, increased risk of cancer, and developmental abnormalities. FANCD2 is a member of the FA gene family and has become the focal point of FA signaling. Research has found that FANCD2 plays an important role in the occurrence and development of tumors and can participate in regulating ferroptosis as a related gene. This article reviews the mechanism of action of FANCD2 and its research progress in tumors, in order to provide new directions and ideas for the diagnosis and treatment of diseases.