The value of IGFBP1 in the diagnosis and prognosis of nasopharyngeal carcinoma
10.3760/cma.j.cn431274-20221214-01314
- VernacularTitle:IGFBP1在鼻咽癌诊断及预后中的价值
- Author:
Yun LUO
1
;
Binliang HUANG
;
Xuchun HUANG
;
Yiwei XU
;
Fangcai WU
Author Information
1. 汕头大学医学院附属肿瘤医院检验科，汕头 515041
- Keywords:
Insulin-like growth factor binding protein 1;
Nasopharyngeal neoplasms;
Biomarkers, tumor
- From:
Journal of Chinese Physician
2023;25(9):1329-1332,1339
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the role of insulin-like growth factor binding protein 1 (IGFBP1) in the diagnosis and prognosis of nasopharyngeal carcinoma (NPC), and to search for molecular markers that can be used for the diagnosis of NPC.Methods:A retrospective analysis was conducted on 150 NPC patients (treated from April 2014 to May 2015) at the Cancer Hospital Affiliated to Shantou University Medical School, and clinical baseline data were collected from 143 healthy individuals (normal control group) during the same period. The serum IGFBP1 concentration was detected using enzyme-linked immunosorbent assay (ELISA) in 112 nasopharyngeal carcinoma patients and 109 normal controls in the training cohort, and was validated in the validation cohort (38 nasopharyngeal carcinoma patients and 34 normal controls). The diagnostic value of serum IGFBP1 in nasopharyngeal carcinoma was evaluated using the receiver operating characteristic curve (ROC).Results:Compared to the normal control group, the expression level of serum IGFBP1 in nasopharyngeal carcinoma patients was higher in the training and validation queues (all P<0.05). In the training queue, the area under the ROC curve was 0.768 (95% CI: 0.706-0.830), with diagnostic specificity and sensitivity of 90.83% and 48.21%, respectively. In the validation queue, the area under the ROC curve was 0.798 (95% CI: 0.697-0.899), with diagnostic specificity and sensitivity of 97.06% and 31.58%, respectively. The predictive values for positive cases in both cohorts were greater than 80%, while the predictive values for negative cases were greater than 50%. The diagnostic threshold for serum IGFBP1 in both cohorts was 1 077 ng/ml. Conclusions:IGFBP1 has practical value as a molecular marker for the diagnosis of nasopharyngeal carcinoma.
