Effect of Qufu Shengji ointment combined with ulinastatin on postoperative wound healing and inflammatory factor levels in perianal surgery
10.12173/j.issn.1008-049X.202311163
- VernacularTitle:祛腐生肌膏联合乌司他丁对肛周术后创面愈合及炎症因子水平影响
- Author:
Ming LU
1
,
2
;
Ke WU
;
Liping MO
;
Guihong RONG
;
Bo CHEN
;
Haining HUANG
;
Bingfen QIN
Author Information
1. 桂林市中西医结合医院肛肠科(广西桂林 541004)
2. 桂林市中西医结合医院秦兵芬广西名中医传承工作室(广西桂林 541004)
- Keywords:
Perianal operation;
Wound healing;
Ulinastatin;
Qufu Shengji ointment;
Inflammatory factors
- From:
China Pharmacist
2024;27(1):117-124
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Qufu Shengji ointment combined with ulinastatin in the treatment of wound healing after perianal surgery and its effect on the level of inflammatory factors.Methods Patients who underwent perianal surgery in Guilin Hospital of Integrated Traditional Chinese and Western Medicine from July 2020 to January 2022 were randomly divided into control group and test group.The patients in both groups were treated with conventional debridement therapy and ulinastatin,and the test group was treated with Qufu Shengji ointment.The wound healing efficacy,TCM symptom score,inflammatory factor level,growth factor level and treatment safety of the two groups were compared.Results A total of 116 patients were included in the study,including 58 patients in the test group and 58 in the control group.The total effective rate of the test group(91.38％)was higher than that of the control group(75.86％),and the difference was statistically significant(P＜0.05).After treatment,the TCM syndrome score levels of interleukin-17A(IL-17A),C-reactive protein(CRP)and serum amyloid A(SAA)in the test group were lower than those in the control group(P＜0.05).The levels of vascular endothelial growth factor receptor 1(VEGFR1),fibroblast growth factor receptor(FGFR)and transforming growth factor-β1(TGF-β1)were higher than those in the control group(P＜0.05).The anal function index was higher than that of the control group(P＜0.05).The incidence of adverse reactions between the two groups was 13.79％and 8.62％,respectively,and the difference was not statistically significant(P＞0.05).Conclusion The effect of Qufu Shengji ointment combined with ulinastatin in the treatment of wound healing after perianal surgery is significant,which can improve the TCM syndrome,reduce inflammatory factors,and upregulate growth factors,and has good safety.
