Optimization of extraction technology for Puji disinfection oral liquid based on combination of G1-entropy weight method and Box-Behnken design-response surface methodology
10.12173/j.issn.1008-049X.202209299
- VernacularTitle:基于Box-Behnken设计-响应面法结合G1-熵权法优化普济消毒口服液的提取工艺
- Author:
Hui-Yue ZHANG
1
;
Lei SUN
;
Ji-Yong WU
Author Information
1. 山东省第二人民医院药学部(济南 250022)
- Keywords:
Puji disinfection oral liquid;
Box-Behnken design-response surface methodology;
G1-entropy weight method;
Subjective and objective combination weighting model
- From:
China Pharmacist
2023;26(12):382-392
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the extraction process of Puji disinfection oral liquid.Methods Based on Box-Behnken design,the extraction process of volatile oil was optimized with the extraction rate of volatile oil as index.Based on Box-Behnken design combined with G1-entropy weight method,the extraction rate and dry extract rate of(R,S)-epigoitrin,hesperidin,baicalin,berberine hydrochloride and arctiin were used as indices to optimize the water extraction process.Results The optimum extraction conditions of volatile oil from Puji disinfection oral liquid were as follows:adding 10 times of water,soaking time of 1.5 h and extraction time of 5 h.The optimal water extraction process was as follows:10 times of water,1.8 h of extraction time and 2 times of extraction.Under the optimal extraction conditions,there was no significant difference among the three batches of verification tests.Conclusion The optimized extraction process is stable and feasible,which can provide the basis for the subsequent experimental study and industrial production of Puji disinfection oral liquid.
