Preparation of Rubus parvifolius L.dispersible tablets and determination of its dissolution rate
10.12173/j.issn.1008-049X.202305019
- VernacularTitle:茅莓分散片的制备及溶出度测定
- Author:
Ming MEI
1
;
Shi-He LIN
;
Jin ZHOU
;
Ming YANG
;
Song HU
Author Information
1. 武汉市第一医院药学部(武汉 430030)
- Keywords:
Rubus parvifolius L.;
Dispersible tablets;
Central composite design-response surface method;
Dissolution rate
- From:
China Pharmacist
2023;26(11):197-203
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the preparation process of Rubus parvifolius L.dispersible tablets and determine its dissolution.Methods On the basis of single factor test,the formulation process of dispersible tablets was optimized by central composite design-response surface method with microcrystalline cellulose(MCC),polyvinyl polypyrrolidone(PVPP)and low substituted hydroxypropyl cellulose(L-HPC)as the influencing factors and disintegration time as the evaluation index.The total saponins of Rubus parvifolius L.was used as an indicator to determine the dissolution rate with reference to the method of Chinese Pharmacopoeia.Results The optimal prescription was 36.9％total saponin extract powder,42％MCC,13％PVPP,8％L-HPC and 0.1％microsilica gel,which showed a high correlation coefficient of the model.The disintegration time of the prepared dispersive tablets was less than 3 min,and the cumulative dissolution rate reached more than 88％at 50 min.Conclusion The optimized process is stable and reliable,and can be used for the preparation of Rubus parvifolius L.dispersible tablets.
