Research progress in roles of fibroblast activation in tissue fibrosis,autoimmune diseases and tumor disease
10.3867/j.issn.1000-3002.2024.03.006
- VernacularTitle:成纤维细胞激活在组织纤维化、自身免疫病和肿瘤中作用的研究进展
- Author:
Xin GU
1
;
Yujiao XU
;
Jiarui SUN
;
Yunyao LIU
;
Lei QIANG
Author Information
1. 中国药科大学基础医学与临床药学学院,江苏 南京 210000
- Keywords:
fibroblast;
activation;
tumor;
fibrosis;
autoimmune disease
- From:
Chinese Journal of Pharmacology and Toxicology
2024;38(3):200-211
- CountryChina
- Language:Chinese
-
Abstract:
Fibroblasts are stromal cells widely distributed in tissues and organs throughout the body.Fibroblasts are involved in the synthesis and remodelling of the extracellular matrix.Fibroblasts participate in physiopathological processes such as tissue damage repair,inflammatory responses and immune regulation.Large numbers of activated fibroblasts have been found in fibrosis,autoimmune diseases and tumor lesions.Activated fibroblasts participate in tissue fibrosis and influence the tumor microenvi-ronment mainly by secreting collagen and fibronectin.They also secrete a variety of inflammatory and growth factors that play an immunomodulatory role in autoimmunity and tumors.In recent years,it has been found that modulating fibroblast activation can effectively delay the development of these diseases,and that targeting fibroblast activation biomarkers can assess the development and treatment of these diseases.Therefore,the use of fibroblast-targeted drugs and therapeutic tools is expected to achieve new breakthroughs in the clinical management of fibrosis,autoimmune diseases and tumors.
