The Anticollagenase Effect of Serum in Alkali-burned Cornea in Rabbit.
- Author:
Dong Hwan PARK
1
;
Byung Joo YOON
Author Information
1. Department of Ophthalmology, National Medical Center, Seoul, Korea.
- Publication Type:Original Article
- MeSH:
Collagenases;
Cornea*;
Corneal Ulcer;
Cysteine;
Edetic Acid;
Matrix Metalloproteinase Inhibitors;
Proteoglycans;
Ulcer
- From:Journal of the Korean Ophthalmological Society
1988;29(4):511-515
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The possible role of collagenase in the development of corneal ulcers has been intensively studied and collagenase inhibitors have been successfully used to control some corneal ulcers. They are cysteine, EDTA, proteoglycan, serum, and medroxyprogesteron, However, most of them are limited in clinical use because of their toxicity and instability except serum, which is not toxic to the host. We carried out an experiment with serum upon alkali-burned rabbit cornea. Serum has potent anticollagenase effect, and prevents corneal ulceration.
