Progress in role of Niemann-Pick C1 protein in Ebola virus infection and its targeted drugs
10.3867/j.issn.1000-3002.2024.02.010
- VernacularTitle:Niemann-Pick C1蛋白在埃博拉病毒感染中的作用及其靶向药物研究进展
- Author:
Haiyan WU
1
;
Guojiang CHEN
Author Information
1. 军事科学院军事医学研究院毒物药物研究所,北京 100850
- Keywords:
Ebola virus;
Niemann-Pick C1 protein;
small molecule inhibitors;
antibody;
gene therapy
- From:
Chinese Journal of Pharmacology and Toxicology
2024;38(2):153-160
- CountryChina
- Language:Chinese
-
Abstract:
Ebola viruses belong to the Filoviridae family,which is highly contagious and likely to cause a variety of symptoms,including severe haemorrhagic fever in humans and primates,with a case fatality rate of up to 90%.Niemann-Pick C1(NPC1)protein is an important receptor expressed in the endosomal membrane of host cells during Ebola virus infection,and its interaction with the glycoprotein(GP)cleaved by cathepsin of Ebola virus is a key link in the viral infection host,mediating the fusion of the viral envelope and endosomal membrane before releasing the viral genome to the host cell.Recent years have seen some small molecule inhibitors and monoclonal antibody gene therapy drugs devel-oped by using NPC1 protein as a target of broad-spectrum anti-filovirus drugs.This article introduces the structure of NPC1 and its role in Ebola virus infection,and summarizes small molecule inhibitors,monoclonal antibody drugs and gene therapy drugs targeting NPC1.
