Research progress in psychopharmacology based on approach-avoidance conflict behavior
10.3867/j.issn.1000-3002.2024.02.009
- VernacularTitle:基于趋避冲突行为的精神药理学研究进展
- Author:
Zhibo ZHANG
1
;
Jingyi JIA
;
Ruiting WEN
;
Linggao ZENG
;
Jianhui LIANG
Author Information
1. 北京大学药学院分子与细胞药理学系,北京 100191
- Keywords:
approach-avoidance conflict;
mental disorder;
cortical-limbic-striatum circuit;
Liang's contextual-stress box
- From:
Chinese Journal of Pharmacology and Toxicology
2024;38(2):144-152
- CountryChina
- Language:Chinese
-
Abstract:
Approach-avoidance conflict(AAC)refers to the internal conflict that individuals experi-ence when faced with conflicting approach or avoidance thoughts.It reveals some characteristics of mental disorders,such as anxiety,depression,and addiction represented by excessive tendencies of approach or avoidance.The function of the cortico-limbic-striatal system influences behavioral choices at the neural level during the onset of AAC,and the development of related behavioral paradigms that can better represent AAC behaviors is critical to evaluating the efficacy of drugs and guiding the development of new drugs.This paper summarizes the neural mechanisms,behavioral paradigms,and applications in behavioral pharmacology related to AAC behaviors from the perspective of psychopharmacology with a view to providing new perspectives and methods for the diagnosis and treatment of related neuro-psychiatric disorders.
