Research progress in astrocyte dysfunction and depression

VernacularTitle:星形胶质细胞功能障碍与抑郁症研究进展
Author: Yongxing QIAO ^{1
,

2} ; Wei DAI ; Haixia WU ; Shuoyu HAN ; Liming ZHANG
Author Information

1. 河北科技大学化学与制药工程学院,河北石家庄 050000
2. 军事科学院军事医学研究院毒物药物研究所,北京 100850
Keywords: depression; astrocytes; monoamines; inflammation; glutamate; synaptic plasticity
From: Chinese Journal of Pharmacology and Toxicology 2024;38(2):137-143
CountryChina
Language:Chinese
Abstract: Most of the current research on depression focuses on neuronal regulation,while the astrocytic mechanism of depression is far from explored.Astrocytes are the most numerous and widely distributed glial cells in the central nervous system.With a complex structural morphology,astrocytes play an important role in a variety of neuropsychiatric disorders by interacting with neuronal synapses,vasculature and other glial cells.Recent studies have shown that astrocytes may be involved in depression by regulating monoamine transmitters,glutamate cycle,synaptic plasticity,energy metabo-lism,and neuroinflammation.This review is intended to inspire new ideas for the treatment of depres-sion and the development of novel drugs based on astrocyte regulation.