Advances in applications of neuroregulatory techniques in research on brain sciences
10.3867/j.issn.1000-3002.2024.02.007
- VernacularTitle:神经调控技术在脑科学研究中的应用研究进展
- Author:
Mengnan LIU
1
;
Xiaoyu TIAN
;
Yitong LI
;
Ning WU
;
Jin LI
;
Hong LI
Author Information
1. 军事科学院军事医学研究院毒物药物研究所,抗毒药物与毒理学国家重点实验室,神经精神药理学北京市重点实验室,北京 100850
- Keywords:
brain science;
mental disorders;
optogenetic technology;
magnetogenetic technology;
chemogenetic technology
- From:
Chinese Journal of Pharmacology and Toxicology
2024;38(2):128-136
- CountryChina
- Language:Chinese
-
Abstract:
Drugs and physical stimulation,including light,electricity,and magnetic fields,can be used to influence how neurons operate,among which chemogenetic and optogenetic technologies are most widely used.In recent years,magnetogenetic technology has also been developed that can acti-vate neurons in magnetic fields through magnetic sensitive actuators,leading to non-invasive and instanta-neous activation of specific brain regions.This article reviews the evolution of and problems with chemoge-netic and optogenetic techniques commonly used in brain science research.It also outlines the latest progress in magnetogenetic technologies,which are not full-fledged yet,as well as the role of transcra-nial electrical stimulation,transcranial magnetic stimulation,deep brain stimulation and transcranial ultra-sound stimulation technology in the functional regulation of brain diseases.Constant adjustment and improvement can make it possible for these technologies to be used more widely for the study of brain sciences and the treatment of brain diseases.
