Advances in research and application of ionizing radiation biomarkers
10.3867/j.issn.1000-3002.2024.01.008
- VernacularTitle:电离辐射生物标志物研究与应用进展
- Author:
Hongling OU
1
;
Wenchao AI
;
Yan WANG
;
Yingying MA
;
Lei SHI
;
Qiaoyun ZHANG
;
Xiujun SONG
;
Xinru WANG
Author Information
1. 火箭军特色医学中心检验科,北京 100088
- Keywords:
ionizing radiation;
molecular diagnostics;
biomarkers
- From:
Chinese Journal of Pharmacology and Toxicology
2024;38(1):70-78
- CountryChina
- Language:Chinese
-
Abstract:
Exposure to ionizing radiation intervenes in genomic stability and gene expression,resulting in the disruption of normal metabolic processes in cells and organs by causing complex biolog-ical responses.Altered genomic variations,gene expression and metabolite concentrations in blood or tissue samples reflect systemic radiation damage.With the application of new techniques and exten-sive study on the mechanisms for ionizing radiation damage,related indicators such as chromosomal variation,gene expression,lipid and metabolism are being recognized and promise to be the markers for early diagnosis and prognosis of radiation exposure.Therefore,this article reviews recent progress in and potential applications of biomarkers related to ionizing radiation injury.
