The Effect of Ketoconazole in the Treatment of Candida albicans Keratitis in Rabbits.
- Author:
Won Ki LEE
1
;
Hyung Jeon KIM
Author Information
1. Department of Ophthalmology, National Medical Center, Seoul, Korea.
- Publication Type:Original Article
- MeSH:
Animals;
Candida albicans*;
Candida*;
Keratitis*;
Ketoconazole*;
Rabbits*;
Spores
- From:Journal of the Korean Ophthalmological Society
1988;29(4):529-533
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Candida albicans keratitis was established in rabbits by intrastromal injection of a suspension containing 1.2 X 10(4) spores. After a 48-hour incubation period, the animals were treated with oral ketoconazole(10mg/kg daily) alone and in combination with topical ketoconazole(2% solution ten times a day) for 2 weeks. Clinical scores were significantly lower in both treated groups than in the control group. But there was no significant difference between the two treated groups.
