Structure and function of neurovascular unit and its role in pathogenesis of cerebral ischemia injuries
10.3867/j.issn.1000-3002.2023.12.001
- VernacularTitle:神经血管单元结构和功能及其在脑缺血损伤发生机制中的作用
- Author:
Heyuan MA
1
;
Qinqing LI
;
Shifeng CHU
;
Zhao ZHANG
;
Wenbin HE
Author Information
1. 山西中医药大学分子中医药学国家国际联合研究中心,中医脑病学山西省重点实验室,山西 太原 030024
- Keywords:
neurovascular unit;
structure and function;
cerebral ischemia;
pathogenesis
- From:
Chinese Journal of Pharmacology and Toxicology
2023;37(12):885-894
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,increasing attention has been paid to the study on the pathogenesis of cerebral ischemia in terms of the overall structure and function of neurovascular unit(NVU),which has become one of the hot spots in the field of brain sciences and major brain diseases.This paper is intended to outline the roles of the four main NVU cells(neurons,astrocytes,microglia and cerebral microvascular endothelial cells)in brain function and pathogenesis of cerebral ischemia,which are closely related in structure,work together to maintain cerebral homeostasis in function,and play an important role in brain function and cerebral ischemic injuries.NVU injury leads to microvascular and blood brain barrier integrity impairment,neuronal cell death,glial reaction and immune cell infiltration,and even tissue injury and brain edema.This paper also aims to elucidate the roles of NVU structure and function in the pathogenesis of cerebral ischemia,and offer new ideas and strategies for the research related to drugs for prevention and treatment of cerebral ischemia based on NVU structure and function.
