Research progress of ferroptosis and its mechanism of action on intestinal epithelial cells in inflammatory bowel disease
- VernacularTitle:铁死亡及其在炎症性肠病中对肠上皮细胞作用机制的研究进展
- Author:
Shuang-Lan CHEN
1
;
Qing-Song LIU
;
Shuang-Yuan HU
;
Yi ZHANG
;
Rong LIU
Author Information
- Keywords: ferroptosis; inflammatory bowel disease; intestinal epithelial cells; oxidative stress; mechanism; research progress
- From: Chinese Pharmacological Bulletin 2023;39(12):2210-2215
- CountryChina
- Language:Chinese
- Abstract: Inflammatory bowel disease(IBD)is a chronic pro-gressive inflammation of the gastrointestinal tract that damages the mucous membrane of the gastrointestinal tract.A growing number of studies have demonstrated that dysfunctional cell death occurs at inflammatory sites,leading to the destruction of the intestinal mechanical barrier and aggravation of inflammatory responses.Ferroptosis is a newly discovered form of programmed cell death mediated by iron-dependent lipid oxidation.There have been many articles that reported intestinal abnormal related factors of ferroptosis in patients with IBD.In view of the unclear current IBD specific pathogenesis and the many limitations in treatment,we summarize the research progress of ferroptosis mechanism in recent years,and expound the potential role of fer-roptosis in the pathogenesis of IBD,aiming to provide direction for the future study of the pathogenesis of IBD and the develop-ment and application of therapeutic drugs.
