Progress in ferroptosis and its inhibitors in central nervous system diseases

VernacularTitle:铁死亡及其抑制剂在中枢神经系统疾病中的研究进展
Author: Yashi WANG ¹ ; Zuoyu HUA ; Lixin ZHANG
Author Information

1. 中国医科大学附属盛京医院康复中心,沈阳 110134
Keywords: central nervous system disease; ferroptosis; iron; lipid peroxidation; inhibitor
From: Journal of China Medical University 2024;53(3):276-281
CountryChina
Language:Chinese
Abstract: The etiology of central nervous system(CNS)diseases is complex and mostly unknown,and patients are often left with sequelae and poor prognosis.Recently,ferroptosis has emerged as a unique oxidative stress-induced cell death pathway and is important in various CNS diseases.It is an important mode of neuronal cell death.This article summarizes the molecular mechanism of ferroptosis,research progress of ferroptosis in CNS diseases,and application of ferroptosis inhibitors in CNS diseases to provide new targets and clini-cal references for CNS disease treatment.