Effect of whey protein on hypoproteinemia in patients with peritoneal dialysis
10.12007/j.issn.0258-4646.2024.02.013
- VernacularTitle:乳清蛋白治疗腹膜透析患者低蛋白血症效果的前瞻性研究
- Author:
Yaozhong SHAO
1
;
Changna LIANG
;
Yingzhou GENG
;
Yinhong JIN
;
Luyuan CHANG
;
Jing LÜ
Author Information
1. 西安交通大学第一附属医院肾脏内科,西安 710061
- Keywords:
whey protein;
peritoneal dialysis;
hypoproteinemia;
therapeutic effect
- From:
Journal of China Medical University
2024;53(2):166-171
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the therapeutic efficacy of whey protein powder in peritoneal dialysis hypoproteinemia patients.Methods From August 2019 to August 2020,100 patients with peritoneal dialysis hypoproteinemia from the Peritoneal Dialysis Center of the First Affiliated Hospital of Xi'an Jiaotong University were investigated.The patients were separated into 2 groups randomly;the study group were administered whey protein powder and the control group with high protein food.After 32 weeks of treatment,biochemical and biometric indices including hemoglobin(Hb),albumin(ALB),prealbumin(PA),triglyceride(TG),total cholesterol(TC),phosphorus(P),low density lipoprotein(LDL),high density lipoprotein(HDL),serum creatinine(Scr),blood urea nitrogen(BUN),estimated glo-merular filtration rate(eGFR),total spKt/Vurea(TKt/V),total creatinine clearance rate(TCcr),hand grip strength(HG),triceps skinfold(TSF),arm circumference(AMC),mid-arm muscle circumference(MAMC)were compared between groups.Results Compared with 0 week,at 16 and 32 weeks,ALB,PA,and HG were significantly increased in the study group(P＜0.05).Compared with the control group,ALB,PA,and HG increased significantly at 16 and 32 weeks in the study group(P＜0.05).There were no significant differences in TG,TC,HDL,LDL,eGFR,TKt/V,and TCcr at 0,8,16,and 32 weeks between the control and study groups(P＞0.05).Conclusion For patients with peritoneal dialysis hypoproteinemia caused by insufficient protein intake or excessive protein loss,the addition of whey protein during peritoneal dialysis can significantly improve the nutritional status of patients,with greater efficacy than a high protein diet alone.
