Relationship between omentin-1,AQP4,and VILIP-1 levels and vascular recanalization after emergency endovascular treatment in patients with acute large vessel occlusion stroke
10.12007/j.issn.0258-4646.2024.02.012
- VernacularTitle:急性大血管闭塞性卒中患者中omentin-1、AQP4、VILIP-1与急诊血管内治疗后血管再通的关系
- Author:
Haijiang ZHANG
1
;
Haimei FAN
;
Jie CHEN
;
Guoyong REN
;
Xuemei WU
Author Information
1. 太原钢铁(集团) 有限公司总医院神经内科,太原 030000
- Keywords:
acute large vessel occlusion stroke;
endovascular treatment;
omentin-1;
aquaporin 4;
visinin-like protein 1
- From:
Journal of China Medical University
2024;53(2):160-165
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between omentin-1,aquaporin 4(AQP4),and visinin-like protein 1(VILIP-1)levels and vascular recanalization after emergency endovascular treatment in patients with acute large vessel occlusion stroke(ALVOS)and their combined predictive efficacy.Methods In total,110 patients with ALVOS undergoing emergency endovascular treatment were categorized into a non-reopening group(23 patients)and a reopening group(87 patients)based on whether the blood vessels were re-opened after surgery.Clinical data and omentin-1,AQP4,and VILIP-1 levels were compared between the two groups.Factors influencing postoperative blood vessel reopening were analyzed,and nomograms were drawn to evaluate their predictive performance and calibration.Results Significant differences were observed in the proportion of patients with hypertension;preoperative NIHSS scores;emergency blood glucose;AQP4,VILIP-1,omentin-1,and platelet levels;time from onset to endovascular treatment;preoperative ASPECTS;and proportion of patients undergoing intravenous thrombolysis between the two groups(P＜0.05).Preoperative ASPECTS and omentin-1 levels were independent protective factors associated with postoperative vascular recanalization,whereas the time from onset to endovas-cular treatment,preoperative NIHSS scores,and AQP4 and VILIP-1 levels were independent risk factors associated with postoperative vascular recanalization(P＜0.05).The C-index of the nomogram for predicting postoperative vascular recanalization was 0.994,and the AUC of the nomogram for predicting postoperative vascular recanalization was 0.994,with a calibration degree of 0.975.Conclusion Omentin-1,AQP4,and VILIP-1 levels are important factors affecting vascular recanalization in patients with ALVOS after emergency endovascular treatment.Clinically,monitoring these levels may help to predict and evaluate early vascular recanalization fol-lowing treatment.
