Role of exercise-related irisin in diabetes mellitus and its complications
10.12007/j.issn.0258-4646.2024.01.014
- VernacularTitle:运动相关的irisin在糖尿病及其并发症中的作用
- Author:
Yutong JIANG
1
;
Jing DING
;
Yi ZHANG
;
Yiping ZHANG
;
Jiwei QIU
;
Yingliang WEI
Author Information
1. 中国医科大学第二临床学院,沈阳 110004
- Keywords:
irisin;
diabetes mellitus;
type 2 diabetes mellitus;
gestational diabetes mellitus;
exercise
- From:
Journal of China Medical University
2024;53(1):86-90,93
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes mellitus is a complex metabolic disease involving multiple organ systems in the body.In recent years,its global incidence rate has increased year by year.In China,the blood glucose control of patients with diabetes mellitus who receive oral hypogly-cemic agents or insulin treatment remains poor.In the early disease stages,exercise is important to control blood glucose levels.Recently,many studies have found that the occurrence of type 2 diabetes mellitus was related to declining levels of irisin,an exercise-related muscle factor.Furthermore,studies have found that irisin improved insulin resistance,promoted the production of pancreatic isletβcells,and affected the body's glucose and lipid metabolism.In addition,its levels were also implicated in the occurrence of various complications,such as diabetic nephropathy and diabetes-related cardiovascular diseases.This article summarizes and analyzes the role of irisin in the occurrence and development of diabetes mellitus and further describes its impact and mechanism on various diabetic complications.
