Effect of Platelet-rich Plasma on Burn Wounds according to Time of Application: An Experimental Study on Rats.
- Author:
San Ha LEE
1
;
Tae Hyun CHOI
;
Suk Wha KIM
Author Information
1. Department of Plastic and Reconstructive Surgery, Seoul National University College of Medicine, Seoul, Korea. psthchoi@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Platelet-rich plasma;
Burns;
Wound healing
- MeSH:
Animals;
Burns;
Fibrin;
Fibroblasts;
Platelet-Rich Plasma;
Rats;
Wound Healing
- From:Journal of Korean Burn Society
2011;14(1):1-5
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: One of the main subjects that burn researches are focused on is saving the zone of stasis. Platelet-rich plasma stimulates angiogenesis, promoting vascular in-growth and fibroblast proliferation. In addition, platelet-rich plasma functions as haemostatic agent by forming a fibrin clot. Also application of platelet-rich plasma enhances wound-healing in both soft and hard tissue. In this study, the effect of the platelet-rich plasma on the zone of stasis was evaluated. METHODS: Sixteen F344/N Slc Inbred Rats were used and randomly separated into four groups. Autologous platelet-rich plasma was harvested and applied to each group of burn wound model at different times. RESULTS: After 20 days, burn wounds of each group healed well. However, healing speed was different in each group. The group to which platelet-rich plasma was applied 4 hours after burn injury had healed about 1.38 times faster than control group. CONCLUSION: The results showed that platelet-rich plasma is an effective substance for saving the zone of stasis. It is not only well-known, but also easy to harvest and easy to use. Thus autologous platelet-rich plasma could be a valuable addition to existing burn treatment methods.
