Effects of microglia in the pathogenesis of major depressive disorder
10.3760/cma.j.cn371468-20240108-00010
- VernacularTitle:小胶质细胞在抑郁症发病机制中的作用
- Author:
Yanjie YANG
1
;
Jili ZHANG
;
Tianyi BU
;
Kexin QIAO
;
Xiaohui QIU
;
Zhengxue QIAO
;
Yu WANG
;
Yu CHEN
;
Bowen WAN
;
Zihang XU
Author Information
1. 哈尔滨医科大学心理科学与健康管理中心，哈尔滨 150081
- Keywords:
Major depressive disorder;
Microglia;
Neurons;
Neuroinflammation
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2024;33(3):278-283
- CountryChina
- Language:Chinese
-
Abstract:
Major depressive disorder (MDD) has become an increasingly serious public health issue, characterized by high incidence and high disability rates. It often coexists with other mental health problems and physical diseases, with a significant negative impact on patients' quality of life. In clinical practice, MDD is considered a heterogeneous disease. The complexity of the pathological mechanisms and the variability in treatment responses lead to a lack of clear therapeutic targets, which complicates the treatment process. In recent years, with advancements in neuroscience, the crucial role of microglia in the pathogenesis of MDD has been revealed. As the main immune cells in the brain, microglia are not only involved in the regulation of neuroinflammation but also play important roles in neurogenesis and neuronal regulation in MDD. This article mainly discusses the role of microglia in the pathophysiological mechanisms of MDD, aiming to provide a theoretical basis for microglia as a potential target for the treatment of MDD.
